Investigating how physical activity and sedentary behavior affect heart failure risk in young adults and midlife.
Official title: Young Adult and Midlife Transitions in Physical Activity and Sedentary Behavior with Heart Failure Risk and Progression: Coronary Artery Risk Development in Young Adults (CARDIA)
Funded at University of Alabama at Birmingham · NIH-10687120 · Data updated 2026-11-12
This study is looking at how being active or sitting too much affects the risk of heart failure in young and middle-aged adults, hoping to find ways to help people stay heart-healthy before any symptoms show up.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | August 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $938,846 |
| NIH project number | 5R01HL149796-04 |
| Project ID | NIH-10687120 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include young adults and midlife individuals who are at risk for heart failure or have sedentary lifestyles.
✕Less likely to help
Patients who are already diagnosed with advanced heart failure may not benefit from this research.
What this research studies
This research examines the relationship between physical activity levels and sedentary behavior with the risk and progression of heart failure, particularly focusing on young adults and midlife individuals. It aims to identify early intervention targets during the preclinical stages of heart failure, which can occur decades before symptoms appear. By analyzing various forms of physical activity, including light intensity and moderate to vigorous activities, the study seeks to uncover how these behaviors influence heart health. The research utilizes data from the Coronary Artery Risk Development in Young Adults (CARDIA) study to explore these connections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing heart failure by promoting healthier physical activity habits in young adults.
How similar studies have gone: Previous research has shown promising results in understanding the impact of physical activity on heart health, but this specific focus on younger populations and preclinical heart failure is relatively novel.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Gabriel, Kelley Pettee — University of Alabama at Birmingham
- Study coordinator: Gabriel, Kelley Pettee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.