Investigating how physical activity affects Alzheimer's disease through blood protein analysis
Official title: Plasma proteomic signatures of physical activity and Alzheimer's disease and related dementias
Funded at University of California, San Diego · NIH-10914261 · Data updated 2026-11-12
This study is looking at how staying active might affect the risk of developing Alzheimer's disease by checking certain proteins in the blood, and it's specifically for women who want to understand more about the connection between exercise and brain health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $102,873 |
| NIH project number | 5K99AG082863-02 |
| Project ID | NIH-10914261 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women over 21 years old who are physically active and at risk for Alzheimer's disease or related dementias.
✕Less likely to help
Patients who are not at risk for Alzheimer's disease or related dementias may not receive benefit from this research.
What this research studies
This research explores the relationship between physical activity and Alzheimer's disease by analyzing blood proteins. It aims to understand how different levels of physical activity, measured through accelerometers, can influence the risk of developing mild cognitive impairment and related dementias. By utilizing advanced machine learning techniques, the study will identify specific protein signatures associated with physical activity and Alzheimer's disease. Participants will be drawn from a large, diverse cohort of women, providing a comprehensive view of the molecular mechanisms involved.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying Alzheimer's disease through targeted physical activity interventions.
How similar studies have gone: Previous research has shown promising results in understanding the impact of physical activity on cognitive health, but this study aims to apply novel machine learning approaches to deepen that understanding.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Nguyen, Steve — University of California, San Diego
- Study coordinator: Nguyen, Steve
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.