Investigating how physical activity affects Alzheimer's disease biomarkers in older adults
Longitudinal Investigation of Cardiorespiratory Fitness and AD Biomarkers in an At-Risk Cohort
This study is looking at how staying active and fit might help people who are at risk for Alzheimer's disease by checking how exercise affects certain markers in the body related to the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10535455 on NIH RePORTER |
What this research studies
This research explores the relationship between cardiorespiratory fitness and biomarkers associated with Alzheimer's disease (AD) in individuals at risk for the condition. By focusing on how physical activity may influence the underlying mechanisms of AD, the study aims to fill critical gaps in knowledge regarding the timing and effects of exercise on brain health. Participants will engage in various forms of aerobic activity, and their fitness levels and AD biomarkers will be monitored over time to assess any changes. The study seeks to provide a clearer understanding of how maintaining physical fitness can potentially alter the course of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those who are at risk for Alzheimer's disease due to age or other factors.
Not a fit: Patients who are not at risk for Alzheimer's disease or who are unable to participate in physical activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying the onset of Alzheimer's disease through physical activity.
How similar studies have performed: Previous research has suggested a positive link between physical activity and reduced risk of Alzheimer's disease, indicating that this approach has potential based on earlier findings.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Okonkwo, Ozioma C — University of Wisconsin-Madison
- Study coordinator: Okonkwo, Ozioma C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.