Investigating how PGI2 affects immune responses in high blood pressure
Official title: PGI2 restrains immunopathogenesis in hypertension
Funded at Trustees of Indiana University · NIH-10993115 · Data updated 2026-11-12
This study is looking at how a substance called PGI2 can help control the immune system's response in people with high blood pressure, with the hope of finding new ways to manage their condition better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $248,999 |
| NIH project number | 5R00HL159594-05 |
| Project ID | NIH-10993115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing hypertension.
✕Less likely to help
Patients with hypertension that is well-controlled or those without any immune-related complications may not benefit from this research.
What this research studies
This research explores the role of PGI2, a metabolite of arachidonic acid, in regulating immune responses related to hypertension. It focuses on how PGI2 can inhibit pro-inflammatory immune cells and promote regulatory immune cells, potentially leading to better blood pressure management. The study involves examining the interactions between immune cells and their impact on blood pressure, aiming to uncover new therapeutic targets for hypertension. Patients may benefit from insights that could lead to novel treatments for managing high blood pressure.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve blood pressure control and reduce cardiovascular risks associated with hypertension.
How similar studies have gone: Previous studies have shown that targeting immune responses can influence hypertension, suggesting that this approach may yield promising results.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Norlander, Allison Elizabeth — Trustees of Indiana University
- Study coordinator: Norlander, Allison Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.