Investigating how PFAS exposure during pregnancy affects blood vessel and placenta function.
Per- and poly-fluoroalkyl substances (PFAS) in pregnancy vascular and placental dysfunction
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11001952
This study is looking at how certain chemicals called PFAS, which can be found in some everyday products, might affect pregnant women and their babies, especially in terms of growth, and aims to find ways to help if problems arise.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11001952 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how exposure to per- and poly-fluoroalkyl substances (PFAS) during pregnancy may lead to complications such as fetal growth restriction (FGR). The study will explore the impact of PFAS on maternal vascular health and placental function through a combination of animal studies, tissue analysis, and molecular techniques. By examining how PFAS affects blood pressure, endothelial function, and nutrient transport to the fetus, the research aims to uncover the mechanisms behind FGR. This could provide insights into potential interventions for affected pregnancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals who may have been exposed to PFAS and are at risk for fetal growth restriction.
Not a fit: Patients who are not pregnant or those without any risk factors for fetal growth restriction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of fetal growth restriction, potentially enhancing outcomes for affected pregnancies.
How similar studies have performed: Previous studies have indicated a link between PFAS exposure and adverse pregnancy outcomes, suggesting that this research builds on established findings rather than exploring a completely novel area.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUMAR, SATHISH — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: KUMAR, SATHISH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.