Investigating how PFAS chemicals affect brain cell health
Elucidation of mitochondrial mechanisms critical to mediating PFAS neurotoxicity
['FUNDING_OTHER'] · MICHIGAN STATE UNIVERSITY · NIH-11064765
This study is looking at how a chemical called PFOS, found in many everyday products, might harm brain cells that produce dopamine, which is important for movement and is affected in Parkinson's disease, to help find new ways to treat or prevent this condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MICHIGAN STATE UNIVERSITY (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-11064765 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the neurotoxic effects of perfluorooctane sulfonic acid (PFOS), a type of PFAS chemical commonly found in everyday products. The study will utilize both laboratory models, including the C. elegans worm and human stem cells, to explore how PFOS may lead to the loss of dopamine-producing brain cells, which is a key feature of Parkinson's disease. By examining the underlying mechanisms of PFOS toxicity, the research aims to uncover potential pathways that could be targeted for therapeutic interventions. Patients may benefit from insights gained into environmental factors contributing to neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals concerned about exposure to PFAS chemicals and those with a family history of neurodegenerative diseases.
Not a fit: Patients who do not have concerns about PFAS exposure or do not have a family history of neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for neurodegenerative diseases linked to environmental toxins.
How similar studies have performed: Previous studies have indicated that PFAS exposure can lead to neurotoxic effects, suggesting that this research builds on established findings in the field.
Where this research is happening
EAST LANSING, UNITED STATES
- MICHIGAN STATE UNIVERSITY — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAMMI, SHREESH RAJ — MICHIGAN STATE UNIVERSITY
- Study coordinator: SAMMI, SHREESH RAJ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.