Investigating how peroxynitrite affects blood vessel energy in Alzheimer's disease
Peroxynitrite is a Molecular Determinant of Impaired Microvascular Energetics in Alzheimer's Disease
This study is looking at how a substance called peroxynitrite affects the energy function of tiny blood vessels in the brain, which are important for thinking and memory in people with Alzheimer's disease, and it aims to find out how age and sex differences in mice might influence this process to help develop new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10877881 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of peroxynitrite in the energy function of brain microvessels, which are crucial for maintaining cognitive function in Alzheimer's disease. Using advanced techniques like the Agilent Seahorse XFe extracellular flux analyzer, the study examines how mitochondrial respiration in these blood vessels is affected by age and sex differences in mice models of Alzheimer's. The researchers aim to uncover the mechanisms behind impaired neurovascular coupling and cognitive decline associated with the disease, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Alzheimer's disease or those at risk of developing it, particularly considering age and sex differences.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in patients with Alzheimer's disease by targeting microvascular energy dysfunction.
How similar studies have performed: While the specific approach of targeting peroxynitrite in microvascular energetics is novel, related research has shown promise in understanding mitochondrial function in Alzheimer's disease.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Katakam, Prasad V — Tulane University of Louisiana
- Study coordinator: Katakam, Prasad V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.