Investigating how peripheral membrane proteins function and developing inhibitors for them
Peripheral membrane proteins and disease: tool development, basic investigations, and inhibitor design
['FUNDING_OTHER'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-10894206
This study is all about finding better ways to understand certain proteins that are important for our health and can be involved in diseases, so researchers can create new treatments that might help people with these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-10894206 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding peripheral membrane proteins (PMPs), which play critical roles in various biological processes and diseases. The team aims to develop new tools and methods to study these proteins in their natural membrane-bound state, which has been challenging with existing techniques. By creating a novel membrane model that mimics cellular membranes, researchers will be able to conduct high-resolution studies and design inhibitors that could lead to new treatments. This work specifically targets important PMPs like glutathione peroxidase 4 and certain domains of NADPH oxidase, which are significant in biomedical research.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions related to the functions of peripheral membrane proteins, such as oxidative stress-related diseases.
Not a fit: Patients with conditions unrelated to the functions of peripheral membrane proteins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new drugs targeting peripheral membrane proteins, potentially improving treatment options for various diseases.
How similar studies have performed: While the study of peripheral membrane proteins is challenging, there is ongoing research in related areas, but this approach using membrane-mimicking models is relatively novel.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FUGLESTAD, BRIAN — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: FUGLESTAD, BRIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.