Investigating how PDL1 affects melanoma growth and progression
The role of tumor cell-of-origin-specific PDL1 on tumorigenesis and tumor progression
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-10913306
This study is looking at how a protein called PDL1 affects the growth of melanoma, a type of skin cancer, using a special mouse model to help find new treatment options for people with this condition.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-10913306 on ClinicalTrials.gov |
What this research studies
This research explores the role of PDL1, a protein that may influence the development and progression of melanoma, a type of skin cancer. Using a specialized mouse model that mimics human melanoma, the study aims to understand how PDL1 signals from tumor cells contribute to tumor growth and response to treatment. The researchers will analyze changes in gene and protein expression as melanoma progresses, particularly focusing on the early stages of tumor development. This could provide insights into new therapeutic strategies targeting PDL1 in melanoma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with melanoma, particularly those in the early stages of the disease.
Not a fit: Patients with advanced melanoma or those who do not express PDL1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with melanoma by targeting PDL1 signaling.
How similar studies have performed: Previous research has shown promising results in targeting PDL1 in other cancers, suggesting potential for success in this area as well.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ONTIVEROS, CARLOS OSCAR — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: ONTIVEROS, CARLOS OSCAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bladder Cancer