Investigating how PDK2 affects heart failure through metabolic and genetic changes
Novel roles of PDK2 in heart failure: Regulation of mitochondrial nuclear crosstalk via metabolic regulation and histone acetylation
['FUNDING_R01'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11047706
This study is looking at a protein called PDK2 to see how it affects the heart's ability to use sugar for energy, which could help us understand heart failure better and find new ways to improve heart health for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11047706 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a specific protein, PDK2, in heart failure. It examines how PDK2 influences the heart's ability to use glucose for energy and how this process is affected by various physiological and pathological conditions. By studying animal models, the researchers aim to uncover the molecular mechanisms behind heart failure and explore potential therapeutic interventions that could improve heart function. Patients may benefit from insights gained about metabolic regulation in heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing heart failure or related cardiac conditions.
Not a fit: Patients with heart conditions unrelated to metabolic regulation or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and outcomes for patients with heart failure.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in heart disease, suggesting that this approach could lead to significant advancements.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WENDE, ADAM RAYMOND — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: WENDE, ADAM RAYMOND
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.