Investigating how PDGFRB signaling affects skin diseases
Official title: PDGFRB Signaling in Progressive Skin Disease
Funded at Oklahoma Medical Research Foundation · NIH-11015763 · Data updated 2026-11-12
This study is looking at a gene called PDGFRB that is linked to skin problems, especially those that make skin look older or thicker, to see how changes in this gene affect skin cells, which could help find better treatments for people with rare skin conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | February 8, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $513,700 |
| NIH project number | 5R01AR080896-03 |
| Project ID | NIH-11015763 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with rare genetic skin disorders associated with PDGFRB mutations.
✕Less likely to help
Patients with common skin conditions unrelated to genetic mutations in PDGFRB may not benefit from this research.
What this research studies
This research focuses on understanding the role of PDGFRB, a gene associated with skin diseases, particularly those that exhibit symptoms of accelerated aging or abnormal skin thickening. By studying genetic mutations in PDGFRB, the research aims to identify how these mutations affect skin cells and contribute to various skin conditions. The approach includes using animal models to manipulate PDGFRB signaling in specific skin cell types, which will help uncover the underlying mechanisms of these diseases. The findings could lead to better understanding and potential treatments for patients with rare genetic skin disorders.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for patients suffering from rare genetic skin diseases.
How similar studies have gone: Previous research has shown promise in understanding genetic mutations related to skin diseases, indicating potential for success in this area.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Olson, Lorin E — Oklahoma Medical Research Foundation
- Study coordinator: Olson, Lorin E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.