Investigating how PD-L1 signaling affects liver health and disease
PD-L1 reverse signaling in liver homeostasis and disease
This study is looking at how a protein called PD-L1 affects the immune system in the liver during infections and diseases, using mice to see how it changes the behavior of immune cells, which could help find new treatments for liver problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11098700 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of PD-L1 reverse signaling in the liver, particularly during acute and chronic infections and diseases. By using a mouse model, the researchers will explore how changes in PD-L1 affect immune cell behavior, including the migration and activation of dendritic cells and T cells. The study aims to uncover the mechanisms by which PD-L1 influences liver conditions, such as fibrosis and immune responses, which could lead to new therapeutic strategies for liver diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with acute or chronic liver diseases or infections.
Not a fit: Patients with liver conditions unrelated to immune regulation or those not experiencing acute or chronic infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver diseases and infections by targeting immune regulation.
How similar studies have performed: Previous research has shown promising results in understanding immune regulation through PD-L1 signaling, suggesting potential for success in this area.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Tamburini, Beth Ann — University of Colorado Denver
- Study coordinator: Tamburini, Beth Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.