Investigating how PD-L1 signaling affects liver health and disease
Official title: PD-L1 reverse signaling in liver homeostasis and disease
Funded at University of Colorado Denver · NIH-11098700 · Data updated 2026-11-12
This study is looking at how a protein called PD-L1 affects the immune system in the liver during infections and diseases, using mice to see how it changes the behavior of immune cells, which could help find new treatments for liver problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | June 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $582,734 |
| NIH project number | 5R01AI186275-02 |
| Project ID | NIH-11098700 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with acute or chronic liver diseases or infections.
✕Less likely to help
Patients with liver conditions unrelated to immune regulation or those not experiencing acute or chronic infections may not benefit from this research.
What this research studies
This research focuses on understanding the role of PD-L1 reverse signaling in the liver, particularly during acute and chronic infections and diseases. By using a mouse model, the researchers will explore how changes in PD-L1 affect immune cell behavior, including the migration and activation of dendritic cells and T cells. The study aims to uncover the mechanisms by which PD-L1 influences liver conditions, such as fibrosis and immune responses, which could lead to new therapeutic strategies for liver diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver diseases and infections by targeting immune regulation.
How similar studies have gone: Previous research has shown promising results in understanding immune regulation through PD-L1 signaling, suggesting potential for success in this area.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Tamburini, Beth Ann — University of Colorado Denver
- Study coordinator: Tamburini, Beth Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.