Investigating how Pax8 affects kidney injury during ischemia.
Official title: Pax8-Hnf4a co-regulation in ischemic kidney injury
Funded at University of Michigan at Ann Arbor · NIH-10948204 · Data updated 2026-11-12
This study is looking at how a protein called Pax8 helps protect kidney cells when they don't get enough blood flow, which can happen during kidney injuries, and it aims to find new ways to help people who are dealing with this kind of damage.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 11, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $117,000 |
| NIH project number | 1R03DK140216-01 |
| Project ID | NIH-10948204 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of acute kidney injury, particularly those with conditions that may lead to ischemia.
✕Less likely to help
Patients with chronic kidney disease unrelated to ischemic injury may not benefit from this research.
What this research studies
This research focuses on understanding the role of the Pax8 protein in kidney cells during ischemic injury, which occurs when blood flow to the kidneys is reduced. The study aims to determine how Pax8 influences the expression of other important genes, particularly Hnf4a, that may protect kidney cells from damage. By analyzing kidney cells in a controlled laboratory setting, researchers hope to uncover the molecular mechanisms that lead to kidney injury and identify potential new treatments for patients suffering from acute kidney injury.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating acute kidney injury, improving outcomes for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding the molecular mechanisms of kidney injury, suggesting that this approach could yield valuable insights.
Where this research is happening
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University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Beamish, Jeffrey Alan — University of Michigan at Ann Arbor
- Study coordinator: Beamish, Jeffrey Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.