Investigating how PAX6 can help create new neurons in the adult brain.
PAX6-induced adult neurogenesis
This study is looking at how a special protein called PAX6 helps the brain create new nerve cells from support cells after an injury, which could lead to new treatments for brain healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10876912 on NIH RePORTER |
What this research studies
This research explores the role of the PAX6 protein in generating new neurons from glial cells in the adult brain, particularly after traumatic injuries. By using advanced techniques like genetic tracing and deep sequencing, the researchers aim to understand the mechanisms behind this process. They will also map the connections of these newly formed neurons and assess their impact on behavior in animal models. The findings could provide insights into potential therapies for neural regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with traumatic brain injuries or conditions that affect neuronal health.
Not a fit: Patients with stable neurological conditions that do not involve neuronal loss or injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for brain injuries and neurodegenerative diseases by promoting the regeneration of neurons.
How similar studies have performed: While the approach of using PAX6 for neurogenesis is innovative, similar studies have shown promise in the field of neural regeneration, suggesting potential for success.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Zhang, Chun-Li — Ut Southwestern Medical Center
- Study coordinator: Zhang, Chun-Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.