Investigating how past coronavirus infections may protect against COVID-19
Serologic and Molecular Studies of human anti-hCoV antibody cross-immunity and protective responses among endemic HCoVs and SARS-CoV2
This study is looking at how past infections with common cold coronaviruses might help protect people from getting seriously ill with COVID-19, and it involves collecting blood samples from both kids and adults to see if they have helpful antibodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10689125 on NIH RePORTER |
What this research studies
This research explores the potential for cross-immunity between common human coronaviruses and SARS-CoV2, particularly focusing on how prior exposure to these viruses may influence the severity of COVID-19 illness. By collecting blood samples from a diverse group of individuals, including children and adults, the study aims to identify and quantify antibodies that could provide protection against COVID-19. The research will analyze both serologic and molecular data to understand the immune response better and its implications for treatment and prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals who have been infected with COVID-19, as well as healthcare providers and pediatric and adult cancer patients.
Not a fit: Patients who have not been exposed to coronaviruses or those with no history of COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of immunity to COVID-19 and inform vaccine development and treatment strategies.
How similar studies have performed: Previous research has indicated that cross-immunity may exist among different coronaviruses, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Marasco, Wayne a. — Dana-Farber Cancer Inst
- Study coordinator: Marasco, Wayne a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.