Investigating how PARP10 helps cancer cells grow and survive stress during DNA replication
The role of PARP10 in alleviating replication stress and promoting cellular proliferation and tumorigenesis
This study is looking at a protein called PARP10 to see how it helps cancer cells survive and grow, with the hope of finding new ways to tailor treatments for patients based on the specific characteristics of their tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-11008915 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of PARP10, a protein that may help cancer cells bypass DNA damage and continue to proliferate. By studying how PARP10 functions in cancer cells compared to normal cells, the researchers aim to identify new therapeutic targets for personalized cancer treatments. The approach involves examining the effects of PARP10 on DNA replication stress and tumor growth in various cancer models. Patients may benefit from insights gained into how their tumors might be treated more effectively based on their unique molecular profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with breast or ovarian cancers that show overexpression of the PARP10 gene.
Not a fit: Patients with cancers that do not involve PARP10 overexpression or those with non-cancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with cancers that exhibit high levels of PARP10.
How similar studies have performed: Previous research has shown that targeting similar pathways in cancer cells can lead to successful treatment outcomes, suggesting that this approach may also yield beneficial results.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Nicolae, Claudia M — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Nicolae, Claudia M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.