Investigating how parathyroid hormone can reduce spinal degeneration and pain in aging
PTH Attenuation of Spinal Degeneration During Aging PI Janet Crane
This study is looking at how a hormone called parathyroid hormone (PTH) might help ease low back pain from spinal wear and tear in older adults by testing it on aged mice to see if it can improve spine health and reduce pain.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11004728 on NIH RePORTER |
What this research studies
This research focuses on understanding how parathyroid hormone (PTH) can help alleviate low back pain caused by spinal degeneration in aging individuals. The study involves administering PTH to aged mice to observe its effects on intervertebral disc (IVD) health and pain behaviors. Researchers are examining how PTH influences the structural integrity of the spine, particularly the vertebral endplate, which is crucial for maintaining spinal health. By restoring cell function and reducing pain sensitivity, this research aims to identify a potential treatment for age-related spinal issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing low back pain related to spinal degeneration.
Not a fit: Patients with low back pain not related to spinal degeneration or those with acute injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce low back pain and improve quality of life for aging patients.
How similar studies have performed: Previous studies have shown promising results with PTH in animal models, indicating potential for success in similar therapeutic approaches.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Crane, Janet — Johns Hopkins University
- Study coordinator: Crane, Janet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.