Investigating how papillomavirus proteins affect cellular targets
Papillomavirus E6 cellular targets
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-10891593
This study is looking at how certain proteins from human papillomavirus (HPV) can interact with our cells to cause benign tumors, and it aims to help people with HPV-related conditions by finding new ways to treat these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10891593 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how proteins from human papillomaviruses (HPV) interact with cellular components to drive the formation of benign tumors known as papillomas. The study examines both high-risk and low-risk HPV types, particularly the E6 protein, which is known to bind to a cellular ligase and influence the degradation of important tumor suppressor proteins. By identifying common cellular targets affected by these viral proteins, the research aims to shed light on the mechanisms of viral oncogenesis and the potential for therapeutic interventions. Patients with HPV-related conditions may benefit from insights gained through this research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with HPV infections, particularly those experiencing complications from papillomas.
Not a fit: Patients who do not have HPV infections or related conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing HPV-related conditions and reducing the risk of complications from papillomas.
How similar studies have performed: Previous research has shown promising results in understanding the interactions between viral proteins and cellular targets, suggesting that this approach could yield significant insights.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VANDE POL, SCOTT BRIAN — UNIVERSITY OF VIRGINIA
- Study coordinator: VANDE POL, SCOTT BRIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.