Investigating how Pannexin 1 channels affect bladder function in diabetes
Pannexin 1 channels, new players in diabetic bladder dysfunction
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-10427295
This study is looking at how type 1 diabetes affects bladder function and aims to find new ways to help people with diabetes who have bladder problems, so they can feel better and improve their quality of life.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-10427295 on ClinicalTrials.gov |
What this research studies
This research explores the changes in bladder function that occur in individuals with type 1 diabetes mellitus (T1DM), focusing on the role of Pannexin 1 channels in bladder dysfunction. The study aims to understand how diabetes affects the bladder's urothelium and to identify new molecular targets for treatment. By examining diabetic mouse models, researchers will investigate the progression from normal bladder function to overactivity and then to underactivity, which can significantly impact quality of life. The goal is to develop better management strategies for patients experiencing underactive bladders due to diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 1 diabetes who are experiencing bladder dysfunction.
Not a fit: Patients without diabetes or those with bladder dysfunction not related to diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve bladder function in patients with diabetes.
How similar studies have performed: While the specific focus on Pannexin 1 channels in diabetic bladder dysfunction is novel, similar research has shown promise in understanding bladder issues related to diabetes.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUADICANI, SYLVIA OTTILIE — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: SUADICANI, SYLVIA OTTILIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Neurogenic Bladder Disorder, Neurogenic Urinary Bladder Disorder