Investigating how pain-sensing nerves affect oral cancer and pain management
TRPV1 nociceptors in oral carcinogenesis and pain
This study is looking at how certain nerves that sense pain might affect the pain and growth of oral cancers, with the goal of finding better ways to help manage pain for people with oral cancer and reduce the need for strong pain medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11045043 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific pain-sensing nerves, known as TRPV1 nociceptors, in the development and pain associated with oral cancers. The study aims to explore how these nerves interact with cancer cells and the surrounding environment, potentially leading to increased pain and cancer progression. By identifying the mechanisms behind these interactions, the research seeks to find new ways to manage pain in oral cancer patients and reduce reliance on opioids. The approach includes examining the characteristics of these nerves and how they are activated by substances released from cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with oral cancer, particularly those experiencing significant pain or with metastatic disease.
Not a fit: Patients with non-cancerous oral conditions or those not experiencing pain related to oral cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies for patients with oral cancer, enhancing their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the role of nociceptors in cancer pain, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Albertson, Donna G — New York University
- Study coordinator: Albertson, Donna G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.