Investigating how P-glycoprotein interacts with drugs and lipids
Drug, Nucleotide, and Lipid Interactions with P-glycoprotein
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11072053
This study is looking at a protein called P-glycoprotein that helps cancer cells resist treatment, and by understanding how it changes shape, we hope to find better ways to make cancer drugs more effective for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11072053 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the P-glycoprotein (P-gp), a protein that plays a crucial role in pumping drugs and other substances out of cells. By examining how P-gp changes shape in response to different conditions, the researchers aim to uncover how it affects drug resistance in cancer cells. The study employs advanced techniques like Hydrogen/Deuterium Exchange Mass Spectrometry to analyze these interactions in a controlled lipid environment. This knowledge could lead to better strategies for overcoming drug resistance in cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers known to exhibit drug resistance due to P-glycoprotein overexpression.
Not a fit: Patients with cancers that do not involve P-glycoprotein-related drug resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve cancer treatment by identifying ways to enhance drug effectiveness against resistant cancer cells.
How similar studies have performed: Previous research has shown that understanding protein interactions can lead to significant advancements in cancer treatment, suggesting this approach has potential for success.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ATKINS, WILLIAM M — UNIVERSITY OF WASHINGTON
- Study coordinator: ATKINS, WILLIAM M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.