Investigating how ozone exposure affects blood clotting risk through oxysterols
Official title: The Effects of Ozone-Induced Oxysterols on Thrombotic Risk
Funded at Univ of North Carolina Chapel Hill · NIH-10998090 · Data updated 2026-11-12
This study is looking at how breathing in ozone might affect heart health by causing changes in cholesterol that could lead to blood clots, and it's for anyone interested in understanding the connection between air quality and cardiovascular issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 11, 2024 |
| Project end | June 11, 2026 |
| Funding year | 2024 |
| Award (this year) | $73,828 |
| NIH project number | 1F32HL176084-01 |
| Project ID | NIH-10998090 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in areas with high ozone levels who may be at risk for cardiovascular issues.
✕Less likely to help
Patients who do not have cardiovascular risk factors or who are not exposed to ozone pollution may not benefit from this research.
What this research studies
This research explores the impact of ozone exposure on cardiovascular health, specifically focusing on how ozone-induced oxysterols may increase the risk of thrombosis. The study examines the biochemical processes that occur when ozone interacts with cholesterol, leading to the formation of oxysterols that can stress endothelial cells and disrupt normal blood coagulation. By analyzing blood samples and using advanced proteomic techniques, the research aims to uncover the relationship between ozone exposure and cardiovascular disease, particularly the mechanisms that contribute to increased thrombotic risk.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for cardiovascular diseases linked to air pollution.
How similar studies have gone: Previous studies have indicated a connection between air pollution and cardiovascular health, suggesting that this research builds on established findings rather than exploring a completely novel area.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Dobson, Drevon a — Univ of North Carolina Chapel Hill
- Study coordinator: Dobson, Drevon a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.