Investigating how oxygen levels affect tau protein changes linked to mitochondrial problems
Probing the Influence of Oxygen Toxicity on Tau Hyperphosphorylation caused by Mitochondrial Dysfunction
['FUNDING_R01'] · UNIVERSITY OF CINCINNATI · NIH-11116935
This study is looking at how too much oxygen can affect brain health and contribute to diseases like Alzheimer's, using mice to see if lower oxygen levels can help protect the brain and improve thinking skills.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CINCINNATI (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11116935 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between oxygen toxicity and tau hyperphosphorylation, which is a key factor in neurodegenerative diseases like Alzheimer's. Using a mouse model with mitochondrial dysfunction, the study examines how reduced oxygen levels can mitigate neurodegeneration and cognitive decline. The researchers aim to understand the molecular mechanisms involved and how they contribute to the progression of Alzheimer's disease and related dementias. By studying these processes, the research seeks to identify potential therapeutic targets for intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-neurodegenerative conditions or those not affected by mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease and other neurodegenerative conditions.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction in neurodegenerative diseases, suggesting that this approach has potential for success.
Where this research is happening
CINCINNATI, UNITED STATES
- UNIVERSITY OF CINCINNATI — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRILLO, ANTHONY STEVEN — UNIVERSITY OF CINCINNATI
- Study coordinator: GRILLO, ANTHONY STEVEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: aging associated disease