Investigating how oxygen levels affect tau protein changes linked to mitochondrial problems
Official title: Probing the Influence of Oxygen Toxicity on Tau Hyperphosphorylation caused by Mitochondrial Dysfunction
Funded at University of Cincinnati · NIH-11116935 · Data updated 2026-11-12
This study is looking at how too much oxygen can affect brain health and contribute to diseases like Alzheimer's, using mice to see if lower oxygen levels can help protect the brain and improve thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | June 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $531,400 |
| NIH project number | 5R01AG084718-02 |
| Project ID | NIH-11116935 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with non-neurodegenerative conditions or those not affected by mitochondrial dysfunction may not benefit from this research.
What this research studies
This research explores the relationship between oxygen toxicity and tau hyperphosphorylation, which is a key factor in neurodegenerative diseases like Alzheimer's. Using a mouse model with mitochondrial dysfunction, the study examines how reduced oxygen levels can mitigate neurodegeneration and cognitive decline. The researchers aim to understand the molecular mechanisms involved and how they contribute to the progression of Alzheimer's disease and related dementias. By studying these processes, the research seeks to identify potential therapeutic targets for intervention.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease and other neurodegenerative conditions.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial dysfunction in neurodegenerative diseases, suggesting that this approach has potential for success.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Grillo, Anthony Steven — University of Cincinnati
- Study coordinator: Grillo, Anthony Steven
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.