Investigating how oxygen levels affect a new type of radiation therapy
Official title: Oxygen Dynamics in FLASH Radiotherapy
Funded at Dartmouth College · NIH-11318679 · Data updated 2026-11-12
This study is looking at a new type of radiation therapy called FLASH-RT to see how it affects oxygen levels in tissues, with the goal of finding ways to better treat cancer while protecting healthy cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | June 21, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $528,430 |
| NIH project number | 7R01CA271330-03 |
| Project ID | NIH-11318679 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients undergoing radiation therapy who may benefit from reduced side effects.
✕Less likely to help
Patients who are not receiving radiation therapy or those with conditions unrelated to cancer may not benefit from this research.
What this research studies
This research explores the effects of ultra-high dose rate radiation therapy, known as FLASH-RT, on oxygen dynamics in tissues. By measuring oxygen levels with high precision, the study aims to understand how FLASH-RT can minimize damage to healthy tissues while effectively targeting tumors. The researchers will compare oxygen consumption during FLASH-RT to conventional radiation therapy to uncover the mechanisms behind the 'FLASH' effect. This could lead to improved treatment strategies for cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer radiation therapy options for cancer patients.
How similar studies have gone: Previous research has shown promising results with similar approaches in radiation therapy, indicating potential for significant advancements.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Pogue, Brian William — Dartmouth College
- Study coordinator: Pogue, Brian William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.