Investigating how oxidative stress contributes to colorectal cancer risk factors
Diversity Supplement to "Biomarkers, mechanisms and modulation of oxidative stress associated risk factors in carcinogenesis"
This study is looking at how things like being overweight and eating unhealthy foods can increase the risk of colorectal cancer, especially in younger people, and it aims to find out how certain genetic changes related to oxidative stress might play a role in this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11071628 on NIH RePORTER |
What this research studies
This research explores the link between oxidative stress and colorectal cancer (CRC), particularly focusing on how lifestyle factors like obesity and poor diet can increase cancer risk. By utilizing advanced techniques such as whole genome sequencing and computational analysis, the project aims to identify specific genetic mutations associated with oxidative stress and their role in cancer development. The study also addresses the concerning trend of early-onset CRC in younger adults, aiming to understand how childhood obesity may influence cancer susceptibility later in life.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of obesity or chronic inflammatory diseases, particularly those under 50 years old who may be at risk for colorectal cancer.
Not a fit: Patients who do not have risk factors associated with colorectal cancer or those who are not interested in lifestyle-related interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and targeted therapies for colorectal cancer, particularly for those at higher risk due to lifestyle factors.
How similar studies have performed: Previous research has shown promising results in understanding the role of oxidative stress in cancer, making this approach both relevant and potentially impactful.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Li, Yun Rose — Beckman Research Institute/city of Hope
- Study coordinator: Li, Yun Rose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.