Investigating how oxidative stress contributes to cancer risk factors
Biomarkers, mechanisms and modulation of oxidative stress associated risk factors in carcinogenesis
This study is looking at how things like diet and being overweight might increase the risk of cancer by causing stress in our cells, and it aims to find out how these factors are connected to cancer by examining tumor samples from patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10919224 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of oxidative stress in promoting cancer, particularly how lifestyle factors like diet and obesity may increase cancer risk. By analyzing tumor samples from patients, researchers will use advanced genomic techniques to identify specific mutational signatures linked to oxidative stress and inflammation. This approach aims to uncover the biological mechanisms that connect these risk factors to cancer development, potentially leading to new prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of colorectal tumors and detailed lifestyle data related to diet and health.
Not a fit: Patients who do not have colorectal tumors or those with non-modifiable cancer risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for cancer prevention by identifying lifestyle changes that reduce oxidative stress.
How similar studies have performed: Previous research has shown promising results in understanding the link between oxidative stress and cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Li, Yun Rose — Beckman Research Institute/city of Hope
- Study coordinator: Li, Yun Rose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.