Investigating how oxidative stress affects tumor growth in Neurofibromatosis type 2.
Redox Signaling in Neurofibromatosis
This study is looking at how certain changes in proteins might help tumors grow in people with Neurofibromatosis type 2 (NF2), with the goal of finding new, easier ways to treat these tumors without needing surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-10898214 on NIH RePORTER |
What this research studies
This research focuses on Neurofibromatosis type 2 (NF2), a condition that leads to the development of multiple tumors in the nervous system. The study aims to understand how oxidative modifications of proteins contribute to tumor growth and survival in NF2 patients. By identifying specific proteins that are altered by oxidative stress, the researchers hope to find new, non-invasive treatment targets that could reduce the need for invasive surgeries. The approach involves detailed biochemical analysis of tumor cells to uncover the mechanisms behind tumor proliferation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Neurofibromatosis type 2 who are experiencing tumor growth.
Not a fit: Patients with other types of tumors or those not diagnosed with Neurofibromatosis type 2 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that minimize the need for surgeries and improve the quality of life for NF2 patients.
How similar studies have performed: While the specific approach of targeting oxidative modifications in NF2 is novel, similar strategies have shown promise in other tumor types, indicating potential for success.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Franco, Maria Clara — Florida International University
- Study coordinator: Franco, Maria Clara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.