Investigating how oxidative stress affects retinal damage in age-related macular degeneration.
Official title: cGAS signaling in oxidative retinal damage
Funded at Ohio State University · NIH-11027499 · Data updated 2026-11-12
This study is looking at how oxidative stress affects age-related macular degeneration (AMD), a common cause of vision loss, to find new ways to help slow down the damage to the retina, which could lead to better treatments for people with AMD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $513,371 |
| NIH project number | 1R01EY036873-01 |
| Project ID | NIH-11027499 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with age-related macular degeneration.
✕Less likely to help
Patients with retinal conditions unrelated to oxidative stress or those without age-related macular degeneration may not benefit from this research.
What this research studies
This research focuses on understanding the role of oxidative stress in age-related macular degeneration (AMD), a leading cause of vision loss. It explores how oxidative stress triggers the release of self-DNA in retinal cells, activating an immune response pathway known as cGAS-STING. By using both chronic and acute mouse models, the study aims to uncover the mechanisms behind this process and identify potential therapeutic targets to slow down retinal degeneration. Patients may benefit from insights that could lead to new treatments for AMD.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow or prevent vision loss in patients with age-related macular degeneration.
How similar studies have gone: Previous research has shown promise in targeting oxidative stress pathways in retinal diseases, indicating potential for success in this approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Kerur, Nagaraj — Ohio State University
- Study coordinator: Kerur, Nagaraj
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.