Investigating how oxidative stress affects kidney fibrosis in older adults
Official title: Targeting oxidative stress-induced epigenetic reprogramming in fibrotic disease
Funded at Texas Tech University · NIH-10606293 · Data updated 2026-11-12
This study is looking at how stress from harmful substances in the environment can change our genes and lead to kidney problems, especially in older adults, and it hopes to find new ways to help treat chronic kidney disease by understanding these changes better.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project start | September 15, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $364,515 |
| NIH project number | 3R15DK121362-01A1S1 |
| Project ID | NIH-10606293 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, particularly those with chronic kidney disease, diabetes, or a history of exposure to environmental toxicants.
✕Less likely to help
Patients with acute kidney injury not related to chronic conditions or those without risk factors for oxidative stress may not benefit from this research.
What this research studies
This research aims to understand how oxidative stress, caused by environmental toxicants and other factors, leads to epigenetic changes that contribute to kidney fibrosis, particularly in older adults. The study will explore the mechanisms behind these changes and how they may drive the progression of chronic kidney disease (CKD). By examining the relationship between oxidative stress and kidney cell behavior, the research seeks to uncover potential targets for future therapies. Patients may be involved in providing samples or data to help elucidate these processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for kidney fibrosis, improving outcomes for patients with chronic kidney disease.
How similar studies have gone: Other research has shown promising results in understanding the role of oxidative stress in various diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Texas Tech University
Lubbock, United States Active
Researchers
- Principal investigator: Singh, Kamaleshwar P — Texas Tech University
- Study coordinator: Singh, Kamaleshwar P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.