Investigating how oxidative stress affects kidney fibrosis
Targeting oxidative stress-induced epigenetic reprogramming in fibrotic disease
This study is looking at how things like pollution, aging, and diabetes can harm your kidneys by changing your DNA, and it aims to find new ways to treat kidney disease by understanding these changes better, with help from patients who can share their samples or information.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-10202799 on NIH RePORTER |
What this research studies
This research focuses on understanding how oxidative stress, caused by environmental toxicants and factors like advanced age and diabetes, leads to changes in the DNA that may drive kidney fibrosis. The study aims to identify the specific epigenetic changes that occur in kidney cells when exposed to oxidative stress, which could help explain why some individuals develop irreversible kidney damage. By examining these mechanisms, the researchers hope to uncover potential targets for new treatments for chronic kidney disease. Patients may be involved in providing samples or data to help elucidate these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include elderly individuals or those with diabetes and chronic kidney disease who are at risk for kidney fibrosis.
Not a fit: Patients with acute kidney injury not related to chronic conditions or those without risk factors for kidney fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating kidney fibrosis, particularly in vulnerable populations.
How similar studies have performed: While the specific approach of targeting oxidative stress-induced epigenetic changes in kidney fibrosis is novel, related research has shown promise in understanding the role of oxidative stress in other fibrotic diseases.
Where this research is happening
Lubbock, United States
- Texas Tech University — Lubbock, United States (Active)
Researchers
- Principal investigator: Singh, Kamaleshwar P — Texas Tech University
- Study coordinator: Singh, Kamaleshwar P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.