Investigating how oxidative stress affects heart cell function
Official title: Cardiac ryanodine receptor and oxidative stress
Funded at University of Arizona · NIH-10895588 · Data updated 2026-11-12
This study is looking at how stress from harmful molecules affects a key part of heart cells that helps control calcium release, which could lead to irregular heartbeats, and it's aimed at finding ways to help people with heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL155492-04 |
| Project ID | NIH-10895588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiac diseases, particularly those experiencing arrhythmias or heart failure.
✕Less likely to help
Patients with non-cardiac conditions or those without any history of heart disease may not benefit from this research.
What this research studies
This research focuses on the cardiac ryanodine receptor (RyR2), which plays a crucial role in calcium release in heart muscle cells. It aims to understand how oxidative stress, caused by reactive oxygen species, alters the function of RyR2, potentially leading to dangerous heart rhythms. The study will explore the molecular mechanisms behind this process and identify specific components that could be targeted for therapeutic intervention. By using rodent models of cardiac disease, researchers will assess how these changes contribute to arrhythmias and heart failure.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart conditions that are caused by abnormal calcium signaling.
How similar studies have gone: Previous research has shown that targeting oxidative stress in cardiac cells can lead to improvements in heart function, suggesting that this approach may be promising.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Hamilton, Shanna — University of Arizona
- Study coordinator: Hamilton, Shanna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.