Investigating how oxidative stress affects chromosome stability
Uncovering the impact of oxidative stress on centromere integrity
This study is looking at how oxidative stress affects the important parts of our chromosomes during cell division, which could help us understand why some cancer cells become unstable and how they might develop.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10998118 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of oxidative stress in compromising the integrity of centromeres, which are crucial for proper chromosome segregation during cell division. By using a specialized system to induce oxidative damage specifically at centromeric DNA, the researchers aim to observe the cellular responses, including DNA repair mechanisms and potential cell cycle disruptions. The study will analyze how these processes may contribute to chromosomal instability, a common feature in cancer cells, and could provide insights into the underlying mechanisms of cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers characterized by chromosomal instability or those at high risk for developing such conditions.
Not a fit: Patients with stable chromosomal integrity or those not affected by oxidative stress-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with chromosomal instability.
How similar studies have performed: Previous research has shown that targeting oxidative stress can lead to significant improvements in understanding cancer biology, indicating potential for success in this novel approach.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Thompson, Lily — Thomas Jefferson University
- Study coordinator: Thompson, Lily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.