Investigating how oxidative stress affects chromosome stability
Official title: Uncovering the impact of oxidative stress on centromere integrity
Funded at Thomas Jefferson University · NIH-10998118 · Data updated 2026-11-12
This study is looking at how oxidative stress affects the important parts of our chromosomes during cell division, which could help us understand why some cancer cells become unstable and how they might develop.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31ES036105-01A1 |
| Project ID | NIH-10998118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers characterized by chromosomal instability or those at high risk for developing such conditions.
✕Less likely to help
Patients with stable chromosomal integrity or those not affected by oxidative stress-related conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of oxidative stress in compromising the integrity of centromeres, which are crucial for proper chromosome segregation during cell division. By using a specialized system to induce oxidative damage specifically at centromeric DNA, the researchers aim to observe the cellular responses, including DNA repair mechanisms and potential cell cycle disruptions. The study will analyze how these processes may contribute to chromosomal instability, a common feature in cancer cells, and could provide insights into the underlying mechanisms of cancer development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with chromosomal instability.
How similar studies have gone: Previous research has shown that targeting oxidative stress can lead to significant improvements in understanding cancer biology, indicating potential for success in this novel approach.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Thompson, Lily — Thomas Jefferson University
- Study coordinator: Thompson, Lily
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.