Investigating how oxidative stress affects cell death during tuberculosis infection
Targeting mediators of oxidative stress to limit hyperinflammatory cell death modalities during Mycobacterium tuberculosis infection
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11125997
This study is looking at how different ways cells die can affect how severe tuberculosis infections get, and it hopes to find out why some people are more likely to get really sick from it, which could help improve treatments for patients with tuberculosis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11125997 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how different types of cell death, particularly necrosis and apoptosis, influence the severity of tuberculosis infections. It aims to identify genetic factors that make certain individuals more susceptible to severe disease by studying the role of a specific gene associated with mitochondrial function. By examining how macrophages, a type of immune cell, respond to Mycobacterium tuberculosis, the research seeks to uncover mechanisms that could predict disease outcomes and improve treatment strategies. Patients with tuberculosis and related conditions may benefit from insights gained through this research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals infected with Mycobacterium tuberculosis, particularly those with co-morbidities like HIV, diabetes, or malnutrition.
Not a fit: Patients who are not infected with Mycobacterium tuberculosis or do not have related co-morbidities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better predictions of disease severity in tuberculosis patients and more targeted treatments.
How similar studies have performed: Previous research has shown that understanding cell death mechanisms in infections can lead to significant advancements in treatment, indicating potential success for this approach.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WATSON, ROBERT OWEN — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: WATSON, ROBERT OWEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, acute infection