Investigating how oxidative stress affects brain function in Alzheimer's disease
Official title: Exploring NOX2-Mediated Network Impairment and Neurodegeneration in Alzheimer's Disease
Funded at J. David Gladstone Institutes · NIH-11052818 · Data updated 2026-11-12
This study is looking at how stress in the body and how the brain uses sugar might affect memory and thinking in people with Alzheimer's, and it hopes to find ways to help improve their brain health using certain medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $842,175 |
| NIH project number | 1R01AG087323-01A1 |
| Project ID | NIH-11052818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or mild cognitive impairment, particularly those experiencing cognitive decline and associated symptoms.
✕Less likely to help
Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the relationship between oxidative stress and brain glucose metabolism in Alzheimer's disease, focusing on how these factors contribute to cognitive decline. It examines the role of pathological proteins like Aβ and hyperphosphorylated Tau, which are associated with Alzheimer's. The study also investigates the impact of network hyperactivity, including subclinical seizures, on cognitive function and aims to develop strategies to mitigate these effects using antiepileptic medications. By understanding these mechanisms, the research seeks to identify potential therapeutic targets for improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in using antiepileptic drugs to improve cognition in Alzheimer's models, indicating that this approach may be effective.
Where this research is happening
-
J. David Gladstone Institutes
San Francisco, United States Active
Researchers
- Principal investigator: Zilberter, Misha Yuri — J. David Gladstone Institutes
- Study coordinator: Zilberter, Misha Yuri
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.