Investigating how oxidative stress affects blood vessels in Alzheimer's disease
Official title: Oxidative stress-induced vascular pathology and dysfunction in Alzheimer’s disease
Funded at University of Kentucky · NIH-10523897 · Data updated 2026-11-12
This study is looking at how blood vessel health affects thinking and memory in Alzheimer's disease by using special imaging techniques on mice, hoping to find clues that could help us understand and spot brain damage related to the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $420,750 |
| NIH project number | 1R21AG074146-01A1 |
| Project ID | NIH-10523897 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline associated with vascular issues.
✕Less likely to help
Patients with non-Alzheimer's forms of dementia or those without cognitive impairment may not benefit from this research.
What this research studies
This research focuses on understanding the relationship between vascular health and cognitive decline in Alzheimer's disease. By using advanced imaging techniques, the study aims to observe how oxidative stress impacts blood vessels in the brain, particularly in a mouse model of Alzheimer's. Researchers will track changes in blood flow and vessel integrity in real-time, which could provide insights into the mechanisms behind cognitive impairment. The goal is to identify specific markers that could indicate vascular damage associated with Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and therapeutic strategies for Alzheimer's disease by targeting vascular health.
How similar studies have gone: While the approach of using oxidative stress models in vascular studies is gaining traction, this specific application in Alzheimer's disease is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Sompol, Pradoldej — University of Kentucky
- Study coordinator: Sompol, Pradoldej
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.