Investigating how oxidative stress affects blood vessels and kidneys in adults born with low birth weight
Official title: NOX4-associated oxidative stress mediates vascular and kidney impairment in the low birth weight adult
Funded at New York Medical College · NIH-10530637 · Data updated 2026-11-12
This study is looking at how being born with a low birth weight can lead to long-term health problems like high blood pressure and kidney disease, and it aims to find ways to reduce these risks and improve health for adults who experienced this.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project start | December 15, 2019 |
| Project end | November 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $410,000 |
| NIH project number | 5R01HL151187-04 |
| Project ID | NIH-10530637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are adults who were born with low birth weight and are experiencing hypertension or kidney issues.
✕Less likely to help
Patients who were not born with low birth weight or do not have related cardiovascular or kidney conditions may not benefit from this research.
What this research studies
This research focuses on understanding the long-term health issues faced by adults who were born with low birth weight, particularly their susceptibility to hypertension and kidney disease. By using a mouse model that mimics the conditions of low birth weight humans, the study aims to explore the role of oxidative stress in causing vascular and kidney impairments. Researchers will test various therapeutic strategies to inhibit oxidative stress and improve health outcomes related to blood pressure and kidney function. The findings could lead to new treatments that specifically target these health issues in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve cardiovascular and kidney health in adults who were born with low birth weight.
How similar studies have gone: Other research has shown promising results in targeting oxidative stress to improve health outcomes in similar populations, indicating that this approach has potential for success.
Where this research is happening
-
New York Medical College
Valhalla, United States Active
Researchers
- Principal investigator: Ratliff, Brian Blake — New York Medical College
- Study coordinator: Ratliff, Brian Blake
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.