Investigating how oxidative stress affects blood vessels and kidneys in adults born with low birth weight
NOX4-associated oxidative stress mediates vascular and kidney impairment in the low birth weight adult
This study is looking at how being born with a low birth weight can lead to long-term health problems like high blood pressure and kidney disease, and it aims to find ways to reduce these risks and improve health for adults who experienced this.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project ID | NIH-10530637 on NIH RePORTER |
What this research studies
This research focuses on understanding the long-term health issues faced by adults who were born with low birth weight, particularly their susceptibility to hypertension and kidney disease. By using a mouse model that mimics the conditions of low birth weight humans, the study aims to explore the role of oxidative stress in causing vascular and kidney impairments. Researchers will test various therapeutic strategies to inhibit oxidative stress and improve health outcomes related to blood pressure and kidney function. The findings could lead to new treatments that specifically target these health issues in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are adults who were born with low birth weight and are experiencing hypertension or kidney issues.
Not a fit: Patients who were not born with low birth weight or do not have related cardiovascular or kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve cardiovascular and kidney health in adults who were born with low birth weight.
How similar studies have performed: Other research has shown promising results in targeting oxidative stress to improve health outcomes in similar populations, indicating that this approach has potential for success.
Where this research is happening
Valhalla, United States
- New York Medical College — Valhalla, United States (Active)
Researchers
- Principal investigator: Ratliff, Brian Blake — New York Medical College
- Study coordinator: Ratliff, Brian Blake
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.