Investigating how oxidative stress affects blood vessel function after gestational diabetes
The role of oxidative stress in reduced microvascular function after gestational diabetes
This study is looking at how stress in the body affects the small blood vessels of women who had gestational diabetes, to see if it can help us find ways to keep their hearts and blood sugar levels healthy in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10874693 on NIH RePORTER |
What this research studies
This research focuses on understanding how oxidative stress impacts the function of small blood vessels in women who have experienced gestational diabetes mellitus (GDM). It aims to explore the relationship between oxidative stress and reduced insulin sensitivity in these women, which may contribute to their increased risk of cardiovascular disease and type II diabetes later in life. The study will involve examining the role of specific enzymes that produce reactive oxygen species and testing whether inhibiting these enzymes can improve blood vessel function. By identifying the mechanisms involved, the research seeks to inform potential preventive strategies for affected women.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have had gestational diabetes and are otherwise healthy.
Not a fit: Patients who have not experienced gestational diabetes or those with existing cardiovascular diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that help prevent cardiovascular disease and type II diabetes in women with a history of gestational diabetes.
How similar studies have performed: Previous research has shown that addressing oxidative stress can improve vascular function, suggesting that this approach may be promising.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Stanhewicz, Anna — University of Iowa
- Study coordinator: Stanhewicz, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.