Investigating how oxidative stress affects a specific gene in sickle cell disease
Oxidative stress mechanisms regulating gamma-globin gene transcription in sickle cell disease
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-10649412
This study is looking at how stress in the body affects a specific gene that could help make a better form of hemoglobin for people with sickle cell disease, and it aims to find new ways to ease the pain and anemia that come with the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10649412 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how oxidative stress influences the regulation of the gamma-globin gene in patients with sickle cell disease (SCD). By examining the mechanisms that silence this gene, which is crucial for producing fetal hemoglobin, the study aims to identify potential therapeutic targets. Researchers will use both genetic and chemical methods in a mouse model of SCD to explore how manipulating oxidative stress can affect gene expression and improve symptoms. The ultimate goal is to find new ways to alleviate the severe anemia and painful crises experienced by SCD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with sickle cell disease who experience severe anemia and vasoocclusive crises.
Not a fit: Patients with other forms of anemia or those who do not have sickle cell disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce symptoms and improve the quality of life for patients with sickle cell disease.
How similar studies have performed: Previous research has shown promise in manipulating gene expression related to hemoglobin production, suggesting that this approach could be effective.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZENNADI, RAHIMA — DUKE UNIVERSITY
- Study coordinator: ZENNADI, RAHIMA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Hb SS disease, HbSS disease, Hemoglobin S Disease, Hemoglobin sickle cell disease, Hemoglobin sickle cell disorder