Investigating how oxidative signaling affects anemia in chronic kidney disease
Official title: The Role of Oxidative Signaling through Na/K-ATPase in PNx-induced Anemia
Funded at Marshall University · NIH-10498130 · Data updated 2026-11-12
This study is looking at how a certain enzyme in the body might be involved in causing anemia in people with chronic kidney disease, and it’s testing whether blocking this enzyme can help improve anemia in these patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marshall University NIH-funded |
| Lab location | 1 site (Huntington, UNITED STATES) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $444,000 |
| NIH project number | 1R15HL164682-01 |
| Project ID | NIH-10498130 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults suffering from anemia related to chronic kidney disease.
✕Less likely to help
Patients with anemia not related to chronic kidney disease or those with other underlying causes of anemia may not benefit from this research.
What this research studies
This research focuses on understanding the role of oxidative signaling through the Na/K-ATPase in anemia caused by chronic kidney disease (CKD). It explores how the interaction between this enzyme and reactive oxygen species may contribute to the accelerated destruction of red blood cells, a condition known as eryptosis. By using a specific peptide to block this signaling pathway in a mouse model, the researchers aim to determine if this approach can reduce anemia in CKD patients. The study seeks to uncover new mechanisms behind anemia that current treatments do not address.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively manage anemia in patients with chronic kidney disease.
How similar studies have gone: Previous research has shown promising results in targeting oxidative stress pathways for treating anemia, suggesting that this approach may hold potential.
Where this research is happening
-
Marshall University
Huntington, United States Active
Researchers
- Principal investigator: Liu, Jiang — Marshall University
- Study coordinator: Liu, Jiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.