Investigating how osteopontin affects inflammation and fibrosis in the prostate
Osteopontin: A Novel Mediator of prostatic inflammation and fibrosis
This study is looking at a protein called osteopontin to see how it might affect inflammation and tissue changes in the prostate, which could help us understand urinary problems in men with prostate issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project ID | NIH-10995288 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of osteopontin, a protein that may contribute to inflammation and fibrosis in the prostate. By using animal models and advanced biomedical engineering techniques, the study aims to explore how this protein influences urinary function and tissue remodeling. Patients may benefit from insights gained about the mechanisms behind lower urinary tract symptoms associated with benign prostatic diseases. The research will also involve functional testing of urinary function in mice to better understand these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are men experiencing lower urinary tract symptoms related to benign prostatic diseases.
Not a fit: Patients with prostate cancer or those not experiencing urinary tract symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for men suffering from lower urinary tract symptoms due to benign prostatic conditions.
How similar studies have performed: While the specific role of osteopontin in prostatic inflammation and fibrosis is being explored, similar research has shown promise in understanding inflammatory processes in other tissues.
Where this research is happening
Norfolk, United States
- Old Dominion University — Norfolk, United States (Active)
Researchers
- Principal investigator: Popovics, Petra — Old Dominion University
- Study coordinator: Popovics, Petra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.