Investigating how Ornithine Decarboxylase Antizyme RNA functions to develop new antibiotics
Official title: Examination of Ornithine Decarboxylase Antizyme RNA Structure and Function from Various Organisms for the Development of Antibiological Agents
Funded at Creighton University · NIH-10730595 · Data updated 2026-11-12
This study is looking at a special type of RNA that helps control cell growth and could lead to new antibiotics, which might help patients in the future.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Creighton University NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $440,999 |
| NIH project number | 1R15GM151702-01 |
| Project ID | NIH-10730595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with bacterial infections that are resistant to current antibiotic treatments.
✕Less likely to help
Patients with viral infections or those who do not have antibiotic-resistant bacterial infections may not receive any benefit from this research.
What this research studies
This research focuses on understanding the structure and function of Ornithine Decarboxylase Antizyme RNA across different organisms. By examining how this RNA interacts with polyamines, which are crucial for cell growth and differentiation, the research aims to uncover new mechanisms that could lead to the development of novel antibiotic agents. The approach involves detailed biochemical assays and molecular biology techniques to analyze RNA behavior and its implications in cell regulation and cancer development. Patients may benefit from potential new treatments that arise from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that are more effective against resistant bacterial infections.
How similar studies have gone: Other research has shown promise in targeting RNA structures for antibiotic development, indicating that this approach could yield significant advancements.
Where this research is happening
-
Creighton University
Omaha, United States Active
Researchers
- Principal investigator: Strauss-Soukup, Juliane K — Creighton University
- Study coordinator: Strauss-Soukup, Juliane K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.