Investigating how orexin receptors affect sleep and methamphetamine addiction
Role of orexin receptors in the abuse- and sleep-related effects of methamphetamine
This study is looking at how sleep problems and methamphetamine use are connected, and it will help us understand how a part of the brain that controls sleep might affect addiction, with the goal of finding better treatments for people dealing with both sleep issues and drug use.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project ID | NIH-10885217 on NIH RePORTER |
What this research studies
This research explores the connection between sleep problems and stimulant use disorder, particularly focusing on methamphetamine. It aims to understand how the orexin system, which regulates sleep and addiction, influences the relationship between sleep impairment and drug abuse. The study will involve experiments with rhesus monkeys to assess how methamphetamine affects sleep patterns and how orexin receptors may play a role in this process. By examining these mechanisms, the research seeks to identify potential treatment strategies for individuals struggling with addiction and sleep issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing stimulant use disorder, particularly those with sleep disturbances.
Not a fit: Patients who do not have stimulant use disorder or related sleep issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve sleep and reduce addiction in patients with stimulant use disorder.
How similar studies have performed: Previous studies have shown promising results in understanding the role of orexin in addiction and sleep, suggesting that this approach may yield valuable insights.
Where this research is happening
Jackson, United States
- University of Mississippi Med Ctr — Jackson, United States (Active)
Researchers
- Principal investigator: Berro, Lais F — University of Mississippi Med Ctr
- Study coordinator: Berro, Lais F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.