Investigating how oral microbiome and aging affect HPV outcomes in people living with HIV
Official title: Multi-Omics Predictors of Oral HPV Outcomes among PLWH
Funded at University of Puerto Rico Med Sciences · NIH-10931335 · Data updated 2026-11-12
This study is looking at how the germs in your mouth, aging, and HPV infections are connected in people living with HIV, and it hopes to find ways to improve health by understanding these relationships better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico Med Sciences NIH-funded |
| Lab location | 1 site (San Juan, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $278,797 |
| NIH project number | 5P20GM148324-02 |
| Project ID | NIH-10931335 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who are virologically suppressed and living with HIV.
✕Less likely to help
Patients who are not living with HIV or are under 21 years of age may not benefit from this research.
What this research studies
This research aims to understand the relationship between the oral microbiome, biological aging, and the persistence of oral HPV infections in individuals living with HIV. By collecting saliva samples from participants at two different time points, the study will analyze how changes in the microbiome and DNA methylation patterns may influence mucosal immunity and the risk of HPV-related complications. Additionally, it will consider socioeconomic and behavioral factors to create a machine learning model that predicts HPV infection outcomes. The goal is to identify potential interventions that could improve health outcomes for these patients.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating HPV infections in people living with HIV.
How similar studies have gone: While the specific combination of factors being studied is novel, previous research has shown that understanding the microbiome and biological aging can impact health outcomes in similar populations.
Where this research is happening
-
University of Puerto Rico Med Sciences
San Juan, United States Active
Researchers
- Principal investigator: Perez-Santiago, Josue — University of Puerto Rico Med Sciences
- Study coordinator: Perez-Santiago, Josue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.