Investigating how oral herpesviruses affect HIV transmission from mother to child
Role of oral herpesvirus microbiota in pathogenesis of HIV mother to child transmission
This study is looking at how certain viruses that cause cold sores and other infections might help HIV spread from mothers to their babies, and it hopes to find new ways to stop this from happening.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10418742 on NIH RePORTER |
What this research studies
This research explores the role of oral herpesviruses in the transmission of HIV from mothers to their infants. It focuses on understanding the molecular mechanisms that allow HIV to persist in infant tonsil epithelial cells, which may lead to infection despite preventive measures. The study examines how interactions between herpes simplex virus, human cytomegalovirus, and Epstein-Barr virus with these cells can influence the release of infectious HIV. By analyzing these interactions, the research aims to identify potential new strategies for preventing mother-to-child transmission of HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women living with HIV and their infants, particularly those at risk of mother-to-child transmission.
Not a fit: Patients who are not pregnant or do not have a risk of HIV transmission from mother to child may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies that significantly reduce the rates of HIV transmission from mothers to infants.
How similar studies have performed: Previous research has shown that understanding viral interactions can lead to breakthroughs in preventing viral transmission, suggesting potential success for this approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Tugizov, Sharof M — University of California, San Francisco
- Study coordinator: Tugizov, Sharof M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.