Investigating how oral dysplasias progress to cancer
Official title: Oral Dysplasias to Carcinomas: Multi-omics Study of Progression
Funded at Georgetown University · NIH-10915559 · Data updated 2026-11-12
This study is looking at how early changes in the mouth can lead to a serious type of cancer, aiming to help patients with these early signs by finding ways to predict and prevent the disease from developing.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $650,973 |
| NIH project number | 5U01DE033348-02 |
| Project ID | NIH-10915559 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with oral epithelial dysplasia who are being monitored for potential progression to oral squamous cell carcinoma.
✕Less likely to help
Patients who do not have oral epithelial dysplasia or those with advanced stages of oral cancer may not benefit from this research.
What this research studies
This research focuses on understanding the progression of oral epithelial dysplasia (OED) to oral squamous cell carcinoma (OSCC), a common and aggressive form of cancer. By studying a detailed cohort of patients with OED over time, the research aims to identify molecular changes that signal the transformation to cancer. The approach integrates clinical data, histopathology, epidemiology, and multi-omics analysis to uncover unique characteristics of OED lesions. This comprehensive methodology seeks to improve risk prediction and preventive strategies for patients at risk of developing OSCC.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and preventive measures for patients at risk of oral cancer.
How similar studies have gone: While there have been few longitudinal studies on OED progression, this research aims to fill a gap by utilizing a large, well-characterized cohort, making it a novel approach in this field.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Rozek, Laura — Georgetown University
- Study coordinator: Rozek, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.