Investigating how oral cancer affects pain signaling and drug delivery mechanisms
Official title: Exploring PAR2 Trafficking in Oral Cancer: Implications for Pain Signaling and Drug Delivery
Funded at New York University · NIH-11055549 · Data updated 2026-11-12
This study is looking at how oral cancer causes pain by affecting a special receptor in the body, and it aims to find better ways to deliver pain relief specifically for people dealing with oral cancer.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $137,050 |
| NIH project number | 1K99DE033792-01A1 |
| Project ID | NIH-11055549 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with oral cancer who experience significant pain.
✕Less likely to help
Patients with oral cancer who do not experience pain or those with other types of cancer may not benefit from this research.
What this research studies
This research focuses on understanding how oral cancer influences pain signaling through a specific receptor called PAR2. By studying the role of proteases released in the cancer environment, the research aims to uncover how these substances activate PAR2 and contribute to pain in patients. The approach involves using advanced techniques to analyze the trafficking and signaling of PAR2 in nerve cells associated with oral cancer. Ultimately, the goal is to develop targeted drug delivery systems that can more effectively manage pain for oral cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies for patients suffering from oral cancer.
How similar studies have gone: Previous research has shown promising results in targeting pain signaling pathways in cancer, suggesting potential for success in this novel approach.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Ramirez Garcia, Paulina Daniela — New York University
- Study coordinator: Ramirez Garcia, Paulina Daniela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.