Investigating how oral bacteria may contribute to Alzheimer's disease
Official title: The role of oral microbially induced exosomes in Alzheimer's disease pathogenesis
Funded at Augusta University · NIH-11053750 · Data updated 2026-11-12
This study is looking at how bacteria from your mouth might be linked to Alzheimer's disease and how tiny particles from these bacteria could affect the disease's progress, helping us understand the connection between oral health and memory problems in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $550,627 |
| NIH project number | 1R01AG087335-01A1 |
| Project ID | NIH-11053750 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older, particularly those with a history of periodontal disease or cognitive decline.
✕Less likely to help
Patients under the age of 65 or those without any signs of cognitive decline or periodontal disease may not benefit from this research.
What this research studies
This research explores the connection between oral bacteria and Alzheimer's disease, particularly focusing on how exosomes from these bacteria might influence the disease's progression. The study aims to understand the mechanisms by which these exosomes can cross the blood-brain barrier and potentially contribute to Alzheimer's pathology. By examining the role of specific oral pathogens, the research seeks to uncover new insights into the relationship between oral health and cognitive decline in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new preventive strategies or treatments for Alzheimer's disease by targeting oral health.
How similar studies have gone: Previous research has indicated a potential link between oral health and Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Elsayed, Ranya — Augusta University
- Study coordinator: Elsayed, Ranya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.