Investigating how opioid use disorder and HIV affect brain cells
The Y-SCORCH Data Generation Center at Yale for Single-Cell Opioid Responses in the Context of HIV
This study is looking at how opioid use disorder and HIV affect the brain's cells, hoping to learn more about the changes that happen in the brain for people dealing with both conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10685384 on NIH RePORTER |
What this research studies
This research focuses on understanding the effects of opioid use disorder (OUD) and HIV on the brain at a cellular level. By analyzing brain tissue from individuals with different conditions, including those with both OUD and HIV, the study aims to identify specific cell types and circuits that are altered by these conditions. Using advanced techniques like single nucleus RNA sequencing, researchers will characterize the cellular changes associated with these syndemic conditions. This comprehensive approach could reveal important insights into how these diseases interact and affect brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with opioid use disorder, those living with HIV, and individuals with both conditions.
Not a fit: Patients who do not have opioid use disorder or HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals suffering from both opioid use disorder and HIV.
How similar studies have performed: Previous research has shown promise in understanding the interactions between addiction and viral infections, but this specific approach using single-cell analysis is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Spudich, Serena S — Yale University
- Study coordinator: Spudich, Serena S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.