Investigating how opioid use affects HIV infection and latency in immune cells
Official title: Single-cell multi-omic analysis of opioid-mediated HIV disease pathogenesis
Funded at University of Michigan at Ann Arbor · NIH-10932341 · Data updated 2026-11-12
This study is looking at how using opioids might affect the way your immune cells respond to HIV, and it’s for people living with HIV who want to help researchers understand how to better manage the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $497,860 |
| NIH project number | 5R61DA059916-02 |
| Project ID | NIH-10932341 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV, especially those who also have a history of opioid use.
✕Less likely to help
Patients who are HIV-negative or do not have a history of substance use may not benefit from this research.
What this research studies
This research focuses on understanding the complex relationship between opioid use and HIV disease progression. It aims to analyze how opioids influence the genetic and epigenetic changes in immune cells, which may affect their ability to control HIV infection. By examining these changes at a single-cell level, the study seeks to uncover the mechanisms that allow HIV to persist in the body despite treatment. Patients may be involved in providing samples or data that help researchers explore these critical interactions.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for curing HIV, particularly in patients with substance use disorders.
How similar studies have gone: Previous research has shown promising results in understanding the effects of substance use on HIV, but this specific approach using single-cell analysis is relatively novel.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Collins, Kathleen L. — University of Michigan at Ann Arbor
- Study coordinator: Collins, Kathleen L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.