Investigating how one-carbon metabolism affects immune cells in tuberculosis
Official title: One-carbon metabolism and immune cell function in tuberculosis
Funded at Rutgers Biomedical and Health Sciences · NIH-10897888 · Data updated 2026-11-12
This study is looking at how certain changes in the body's metabolism affect immune cells when fighting tuberculosis (TB), with the hope of finding new ways to boost the immune response against this infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | August 2, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $769,821 |
| NIH project number | 5R01AI177788-02 |
| Project ID | NIH-10897888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are at risk for or currently have tuberculosis.
✕Less likely to help
Patients with non-infectious diseases or those who do not have tuberculosis may not benefit from this research.
What this research studies
This research explores the relationship between one-carbon metabolism and immune cell function in tuberculosis (TB). By studying animal models, the researchers aim to understand how metabolic changes in immune cells respond to TB infection. They utilize advanced techniques like metabolomics and transcriptomic profiling to identify key metabolic pathways that could influence the immune response to TB. The findings may lead to new strategies for enhancing immune function against this infectious disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for tuberculosis by enhancing immune responses.
How similar studies have gone: Previous research has shown promising results in understanding metabolic pathways in immune responses, suggesting potential for success in this area.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Shi, Lanbo — Rutgers Biomedical and Health Sciences
- Study coordinator: Shi, Lanbo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.